| Date | Location | Result | |
| Nov 25, 2000 | Lubbock, Texas | Texas Tech 3, Iowa State 0 (15-2,15-7,15-5) | Box score |
| Nov 20, 2000 | Ames, Iowa | Baylor 3, Iowa State 0 (15-13,15-4,15-9) | Box score |
| Nov 15, 2000 | Lincoln, Neb. | Nebraska 3, Iowa State 0 (15-5,15-11,15-1) | Box score |
| Nov 11, 2000 | Ames, Iowa | Texas A&M 3, Iowa State 0 (15-3,15-12,15-3) | Box score |
| Nov. 8, 2000 | Boulder, Colo. | Colorado 3, Iowa State 0 (15-8,15-6,15-9) | Box score |
| Nov. 4, 2000 | Ames, Iowa | Oklahoma 3, Iowa State 0 (15-7,15-7,15-8) | Box score |
| Oct 31, 2000 | Lawrence, Kan. | Kansas 3, Iowa State 0 (15-2,15-4,15-6) | Box score |
| Oct 28, 2000 | Columbia, Mo. | Missouri 3, Iowa State 0 (15-5,15-5,15-5) | Box score |
| Oct 25, 2000 | Ames, Iowa | Texas 3, Iowa State 0 (15-12,15-6,15-2) | Box score |
| Oct 21, 2000 | Manhattan, Kan. | Kansas State 3, Iowa State 0 (15-2,15-6,15-1) | Box score |
| Oct 18, 2000 | Ames, Iowa | Texas Tech 3, Iowa State 0 (15-7,15-7,15-10) | Box score |
| Oct 16, 2000 | Ankeny, Iowa | Drake 3, Iowa State 2 (10-15,15-7,15-7,11-15,15-10) | Box score |
| Oct 14, 2000 | Waco, Texas | Baylor 3, Iowa State 1 (15-6,15-11,14-16,15-7) | Box score |
| Oct 11, 2000 | Ames, Iowa | Northern Iowa 3, Iowa State 0 (15-6,15-6,15-7) | Box score |
| Oct. 8, 2000 | Ames, Iowa | Nebraska 3, Iowa State 0 (15-0,15-5,15-4) | Box score |
| Oct. 4, 2000 | College Station, TX | Texas A&M 3, Iowa State 0 (15-5,15-1,15-9) | Box score |
| Sep 30, 2000 | Ames, Iowa | Colorado 3, Iowa State 0 (15-11,15-7,15-4) | Box score |
| Sep 27, 2000 | Norman, Okla. | Oklahoma 3, Iowa State 2 (15-8,18-20,11-15,15-3,15-8) | Box score |
| Sep 23, 2000 | Ames, Iowa | Kansas 3, Iowa State 0 (15-7,15-6,15-11) | Box score |
| Sep 20, 2000 | Boone, Iowa | Missouri 3, Iowa State 0 (15-8,15-5,15-5) | Box score |
| Sep 16, 2000 | Austin, Texas | Texas 3, Iowa State 0 (15-5,15-7,15-5) | Box score |
| Sep 13, 2000 | Ames, Iowa | Kansas State 3, Iowa State 0 (15-6,15-5,15-9) | Box score |
| Sep. 9, 2000 | Wichita, Kan. | Iowa State 3, Wichita State 2 (15-13,14-16,3-15,15-12,15-11) | Box score |
| Sep. 9, 2000 | Wichita, Kan. | Butler 3, Iowa State 1 (16-14,15-8,13-15,15-9) | Box score |
| Sep. 8, 2000 | Wichita, Kan. | Louisiana Tech 3, Iowa State 1 (15-7,15-6,4-15,15-6) | Box score |
| Sep. 8, 2000 | Wichita, Kan. | Montana 3, Iowa State 1 (15-9,15-4,14-16,15-8) | Box score |
| Sep. 2, 2000 | Ames, Iowa | Idaho 3, Iowa State 0 (15-7,15-10,15-5) | Box score |
| Sep. 2, 2000 | Ames, Iowa | Iowa State 3, UNC Greensboro 1 (15-9,15-3,12-15,15-4) | Box score |
| Sep. 1, 2000 | Ames, Iowa | Creighton 3, Iowa State 0 (15-0,15-12,15-9) | Box score |